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The study examines the North-South Economic Corridor (NSEC) from a multi-sectoral perspective, reviewing spatial development options, and addressing practical infrastructure, human resource, policy, regulatory and institutional barriers to trade, investment, and the movement of goods and people. It also examines issues related to the strategic development of the NSEC. To that end, it summarizes the various initiatives related to the development of the NSEC and it identifies opportunities and challenges from the economic integration process in an effort to provide an understanding about the substantial potential benefits that are arising from current infrastructure investments, coupled with the ongoing progress on cross-border cooperation among GMS countries. It synthesizes these findings in logical framework that will be used for the analysis of the overall development strategy.